Isometric exercises were performed in the sitting position Patients also performed 5 circles at each angle, with 1 min betweenĬircles. Of relaxation, repeated 10 times for one exercise circle. The quadriceps femoris at angles of 0° and 90° from the knee joint.Ĭontractions were held continuously for 10 sec followed by 10 sec Kinesitherapy included knee joint flexion andĮxtension (active exercise) followed by isometric contraction of Group received oral diclofenac sodium (75 mg, twice daily) and The patients in the control group received oralĭiclofenac sodium (75 mg, twice daily). System diseases mental illness pregnancy and lactation and knownĪllergy to diclofenac. ExclusionĬriteria included: significant stenosis of the joint space or boneīridge connection between the joints manifested as bony ankylosis ĭisease classification IV by X-ray primary disease of the kneeĪffecting joint structures active gastrointestinal diseases and/orĮsophageal or peptic ulcer within 30 days of the trial concurrentĬardiovascular, cerebrovascular, liver, kidney or hematopoietic Years and a disease classification of I-III by X-ray. KOA not receiving other treatment methods or medication age 40–70 Inclusion criteria included: diagnostic criteria of Patients with a,b, or a,c,e,f, or a,d,e,f combinations of the aboveĬriteria were confirmed. Stiffness <30 min and f) crepitation during knee motion. The numbers of patients having disease durations of The patients in the control group received onlyĭaily oral diclofenac sodium. The patients in the treatment group receivedĭaily oral diclofenac sodium (Difene ®) and Into the treatment and control groups according to the order of Yancheng City from January 2010 to December 2011. Years) were diagnosed with KOA in the First People’s Hospital of Patients (n=100, 38 male and 62 female, aged 41–63 Materials and methods Clinical design Study sample Metalloproteinase 3 (MMP-3) in the synovial fluid. Sensitivity C-reactive protein (hs-CRP) and matrix TheĬurrent study used kinesitherapy to treat patients with KOA andĮxplored its mechanism of action by concurrently measuring kneeįunction and the levels of tumor necrosis factor-α (TNF-α), high Kinesitherapy may provide therapeuticĮffects in the treatment of KOA ( 2– 3). Involving the finger joints, knees, spine and hip ( 1). Joint swelling, limited mobility and joint deformities, usually Include degeneration, loss of articular cartilage and osteophyteįormation in the articular cartilage and the lower border of theĬartilage that manifests as joint pain, tenderness, stiffness, In brief, exercise therapy may decrease cytokine and cytokine-related gene levels in the synovial fluid and inhibit inflammatory factor-mediated cartilage degradation in KOA patients, thus, effectively improving the clinical symptoms of KOA.ĭegenerative arthropathy and hypertrophic arthritis, is one of the Compared with the control group, the knee joint index score and the TNF-α, hs-CRP and MMP-3 levels in the synovial joints were lower and the therapeutic efficacy was increased in the patients of the treatment group (P<0.05). The results revealed that the knee joint index score and the TNF-α, hs-CRP and MMP-3 levels in the synovial fluid decreased significantly in the KOA patients of the two groups following treatment (P<0.05). The function of the knee joint and the therapeutic efficacy was evaluated and the TNF-α, hs-CRP and MMP-3 levels in the synovial fluid were measured following 4 weeks of treatment. The patients in the treatment group were treated with diclofenac sodium combined with exercise therapy and the patients in the control group were treated with diclofenac sodium only. A total of 100 KOA patients were divided into a treatment group (n=50) and a control group (n=50) according to the order of admission. The aims of this study were to observe the effect of exercise therapy on the function of the knee joint and the levels of cytokines and cytokine-related genes, specifically tumor necrosis factor-α (TNF-α), high sensitivity C-reactive protein (hs-CRP) and matrix metalloproteinase-3 (MMP-3), in the synovial joints of patients with knee osteoarthritis (KOA) and to explore its mechanism of action.
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